Faktor Koreksi Ionization Chamber pada Dosimetri Berkas Elektron: Kualitas Berkas, Polaritas, dan Rekombinasi Ion di Berbagai Kondisi Pengukuran

Authors

  • Falah Putra Caesarianto Universitas Indonesia Author
  • I Wayan Krisnanda Universitas Indonesia Author
  • Bernike Hernita Sofiana Universitas Indonesia Author

DOI:

https://doi.org/10.35895/rf.v6i2.101

Keywords:

Ultra-high dose rate, FLASH radiotherapy, dose per pulse, small-field dosimetry, ionization chamber design

Abstract

Ionization chamber dosimetry in electron beam radiotherapy required accurate correction for beam quality, polarity effects, and ion recombination. This review examined current evidence on these correction factors under conventional, high dose rate electron, ultra-high dose rate, extended source-to-surface distance, and small-field conditions, with emphasis on recent updates to international electron dosimetry formalisms. Updated Monte Carlo calculations for the beam quality correction factor produced values approximately 0.5% lower than older protocol tabulations, while multicenter experimental data showed that inter-institutional variability remained within the ±2% clinical tolerance. For the polarity correction factor, dose per pulse, electrode spacing, field size, and cable geometry were identified as the main determinants, with cable irradiation producing large apparent polarity corrections in large-field and high dose rate electron beams. For the ion recombination correction factor, conventional two-voltage analysis was reliable only up to approximately 10 mGy per pulse; above this range, empirical logistic models provided more accurate correction estimates. Sub-millimeter electrode spacing and high electric field strength were the most important chamber design parameters for ultra-high dose rate dosimetry. Overall, correction factor uncertainties remained controlled under conventional reference conditions but increased substantially under high dose-per-pulse and non-reference geometries, which current protocols did not adequately cover. These findings supported the need for dedicated dosimetry protocols for high dose rate electron, ultra-high dose rate, extended source-to-surface distance, and small-field electron beam modalities.

References

Alfonso, R., Andreo, P., Capote, R., Huq, M. S., Kilby, W., Kjäll, P., MacKie, T. R., Palmans, H., Rosser, K., Seuntjens, J., Ullrich, W., & Vatnitsky, S. (2008). A new formalism for reference dosimetry of small and nonstandard fields. Medical Physics, 35(11), 5179–5186. https://doi.org/10.1118/1.3005481

Alissa, M., Zink, K., Röser, A., Flatten, V., Schoenfeld, A. A., & Czarnecki, D. (2024). Monte Carlo calculated beam quality correction factors for high energy electron beams. Physica Medica, 117(1), 103179. https://doi.org/10.1016/j.ejmp.2023.103179

Almond, P. R., Biggs, P. J., Coursey, B. M., Hanson, W. F., Huq, M. S., Nath, R., & Rogers, D. W. O. (1999). AAPM ’s TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams. Medical Physics, 26(9), 1847–1870. https://doi.org/https://doi.org/10.1118/1.598691

Bourgouin, A., Paz-Martín, J., Gedik, Y. C., Frei, F., Peier, P., Rossomme, S., et al. (2023). Charge collection efficiency of commercially available parallel-plate ionisation chambers in ultra-high dose-per-pulse electron beams. Physics in Medicine and Biology, 68(23), 235002.

Burns, D. T., Ding, G. X., & Rogers, D. W. O. (1998). R 50 as a beam quality specifier for selecting stoppingpower ratios and reference depths for electron dosimetry. Medical Physics, 23(3), 383–388. https://doi.org/10.1118/1.597893

Butler, D. J., & Healy, B. J. (2025). The contribution of the cable to the polarity effect in ionization chamber dosimetry. Journal of Applied Clinical Medical Physics, 26, e70327. https://doi.org/10.1002/acm2.70327

Calvo, F. A., Sole, C. V., Herranz, R., Lopez-Bote, M., Pascau, J., Santos, A., Muñoz-Calero, A., Ferrer, C., & Garcia-Sabrido, J. L. (2013). Intraoperative radiotherapy with electrons: Fundamentals, results, and innovation. Ecancermedicalscience, 7(1). https://doi.org/10.3332/ecancer.2013.339

Claessens, M., Vanreusel, V., Gasparini, A., de Freitas Nascimento, L., Yalvac, B., Reniers, B., et al. (2024). Automated determination of the ion-recombination correction factor (ksat) in ultra-high dose rate electron radiation therapy. Medical Physics, 51, 4536–4545.

Das, I. J., Ding, G. X., & Ahnesjö, A. (2008). Small fields: Nonequilibrium radiation dosimetry. In Medical Physics (Vol. 35, Number 1, pp. 206–215). John Wiley and Sons Ltd. https://doi.org/10.1118/1.2815356

Dewi, R. S., Limena, M., Kuncoro Sihono, D. S., Yadav, P., & Pawiro, S. A. (2026). Investigation of ion recombination and polarity effects in high dose rate electron beams. Journal of Applied Clinical Medical Physics, 27, e70600. https://doi.org/10.1002/acm2.70600

Erazo, F., Brualla, L., & Lallena, A. M. (2017). Computation of the electron beam quality kQ,Q 0 factors for the NE2571, NE2571A and NE2581A thimble ionization chambers using PENELOPE. Physica Medica, 38, 76–80. https://doi.org/10.1016/j.ejmp.2017.05.053

Gibbons, J. P. (2020). Khan’s the Physics of Radiation Therapy (Sixth Edition). Wolters Kluwer Health.

IAEA. (2000). TECHNICAL REPORTS SERIES No. 398 - Absorbed Dose Determination in External Beam Radiotherapy.

IAEA. (2017). Dosimetry of Small Static Fields Used in External Beam Radiotherapy: An International Code of Practice for Reference and Relative Dose Determination. Technical Reports Series No. 483. http://www-ns.iaea.org/standards/

IAEA. (2024). TECHNICAL REPORTS SERIES No. 398 (Rev. 1) Absorbed Dose Determination in External Beam Radiotherapy.

Inan, G., & Vefa Gul, O. (2026). Evaluation of dosimetric characteristics in small field electron beam parameters using different dosimeters. Radiation Physics and Chemistry, 240. https://doi.org/10.1016/j.radphyschem.2025.113438

Ito, T., Kosaka, H., Yanagi, Y., Sakai, Y., & Monzen, H. (2025). Impact of extended source-to-surface distances and respiratory motion on the precision of electron beam therapy. Journal of Applied Clinical Medical Physics, 26, e70301. https://doi.org/10.1002/acm2.70301

Khan, F. M. (1991). Clinical electron-beam dosimetry: report of Task Group No. 25, Radiation Therapy Committee, AAPM. Published for the American Association of Physicists in Medicine by the American Institute of Physics.

Kranzer, R., Poppinga, D., Weidner, J., Schüller, A., Hackel, T., Looe, H. K., et al. (2021). Ion collection efficiency of ionization chambers in ultra-high dose-per-pulse electron beams. Medical Physics, 48(2), 819–830.

Lang, X., Hu, Z., Li, M., Tang, K., Li, J., Luo, F., et al. (2025). Dosimetric saturation effect study and correction calculation method of ionization chamber at ultra-high dose rate (FLASH). Radiation Physics and Chemistry, 226, 112344.

Lee, U. S., Kim, S. W., Shin, J. B., Jeong, C., Goh, Y., Park, M. J., Kwak, J., Song, S. Y., & Cho, B. (2025). Intraoperative radiotherapy IORT applicators for treatment of small skin lesions a phantom and planning study. Scientific Reports, 15(1). https://doi.org/10.1038/s41598-025-89859-4

Liu, K., Holmes, S., Hooten, B., Schüler, E., & Beddar, S. (2024a). Evaluation of ion chamber response for applications in electron FLASH radiotherapy. Medical Physics, 51, 494–508.

Liu, K., Holmes, S., Khan, A. U., Hooten, B., DeWerd, L., Schüler, E., et al. (2024b). Development of novel ionization chambers for reference dosimetry in electron FLASH radiotherapy. Medical Physics, 51, 9275–9289.

Mahfirotin, D. A., Ferliano, B., Handika, A. D., Asril, Y. S., Fadli, M., Ryangga, D., Nelly, N., Kurniawan, E., Wibowo, W. E., & Pawiro, S. A. (2023). A multicenter study of modified electron beam output calibration. Journal of Applied Clinical Medical Physics, 1–10. https://doi.org/10.1002/acm2.14232

Mcewen, M., Dewerd, L., Ibbott, G., Followill, D., Rogers, D. W. O., Seltzer, S., Dewerd, L., Ibbott, G., & Followill, D. (2014). Addendum to the AAPM ’ s TG-51 protocol for clinical reference dosimetry of high- energy photon beams. Medical Physics, 41(4). https://doi.org/10.1118/1.4866223

Mihailescu, D., Pimpinella, M., Guerra, A. S., & Laitano, R. F. (2005). COMPARISON OF MEASURED AND MONTE CARLO CALCULATED DOSE DISTRIBUTIONS FOR THE NOVAC7® LINEAR ACCELERATOR.

Motta, S., Dal Bello, R., Christensen, J. B., Bossin, L., & Yukihara, E. G. (2024). Dosimetry of ultra-high dose rate electron beams using thermoluminescence and optically stimulated luminescence detectors. Physics in Medicine and Biology, 69(3), 035022.

Muir, B., Davis, S., Dhanesar, S., Hillman, Y., Lakovenko, V., Kim, G. G.-Y., Alves, V. G. L., Lei, Y., Lowenstein, J., Renaud, J., Sarfehnia, A., Siebers, J., & Tantot, L. (2024). AAPM WGTG51 Report 385 : Addendum to the AAPM ’s TG-51 protocol for clinical reference dosimetry of high-energy electron beams. Medical Physics, 51(6), 5840–5857. https://doi.org/10.1002/mp.17277

Muir, B. R., & Rogers, D. W. O. (2014). Monte Carlo calculations of electron beam quality conversion factors for several ion chamber types. Medical Physics, 41(11), 1–15. https://doi.org/10.1118/1.4893915

Palmiero, A., Liu, K., Colnot, J., Chopra, N., Neill, D., Connell, L., et al. (2025). On the acceptance, commissioning, and quality assurance of electron FLASH units. Medical Physics, 52, 1207–1223.

Pawiro, S. A., Wibowo, W. E., & Assegab, M. I. (2022). Modified electron beam output calibration based on IAEA Technical Report Series 398. Journal of Applied Clinical Medical Physics, 23, 1–9. https://doi.org/10.1002/acm2.13573

Paz-Martín, J., Schüller, A., Bourgouin, A., Gago-Arias, A., González-Castaño, D. M., Gómez-Fernández, N., et al. (2025). Evaluation of the two-voltage method for parallel-plate ionization chambers irradiated with pulsed beams. Medical Physics, 52, 4894–4909.

Petersson, K., Jaccard, M., Germond, J. F., Buchillier, T., Bochud, F., Bourhis, J., et al. (2017). High dose-per-pulse electron beam dosimetry: A model to correct for the ion recombination in the Advanced Markus ionization chamber. Medical Physics, 44(3), 1157–1167.

Podgorsak. (2005). Radiation Oncology Physics: A Handbook for Teachers and Students.

Poppinga, D., Kranzer, R., Farabolini, W., Gilardi, A., Corsini, R., Wyrwoll, V., et al. (2021). VHEE beam dosimetry at CERN Linear Electron Accelerator for Research under ultra-high dose rate conditions. Biomedical Physics & Engineering Express, 7(1), 015012.

Rustgi, S. N., & Working, K. R. (1992). Dosimetry of Small Field Electron Beams. Medical Dosimetry, 17(2), 107–110. https://doi.org/10.1016/0958-3947(92)90023-9

Sempau, J., Andreo, P., Aldana, J., Mazurier, J., & Salvat, F. (2004). Electron beam quality correction factors for plane-parallel ionization chambers : Monte Carlo calculations using the PENELOPE system. Physics in Medicine and Biology, 49, 4427–4444. https://doi.org/10.1088/0031-9155/49/18/016

Yanagi, Y., Monzen, H., Kubo, K., Sugiyama, J., Noma, K., Ito, T., et al. (2023). Comparison of the characteristics of two types of parallel-plate ionization chamber under small-field electron irradiation. Anticancer Research, 43(5), 1967–1972.

Zink, K., & Wulff, J. (2008). Monte Carlo calculations of beam quality correction factors kQ for electron dosimetry with a parallel-plate Roos chamber. Physics in Medicine and Biology, 53, 1595–1607. https://doi.org/10.1088/0031-9155/53/6/006

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2026-07-31

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